These changes are most likely to be vascular in origin and will usually be found in the presence of severe intrauterine growth restriction (IUGR).
Other features of IUGR will be present. The condition has rarely been described. Hepatic necrosis is not associated with any known chromosomal or genetic syndromes. However it is generally recognised because of the presence of intrahepatic calcification, which may be due to a number of different causes, including ischemia and congenital infections due to agents such as varicella, cytomegalovirus, rubella or toxoplasmosis.
It is not possible to indicate a differential diagnosis. Disturbances of the appearance of the liver might suggest a diaphragmatic hernia.
Increased echodensity usually affecting the left side of the liver
The affected liver may eventually show areas of calcification
1. Nguyen DL, Leonard JC Ischaemic hepatic necrosis ; a cause of fetal liver calcification Am J Roentgenol 147; 596-597
2. Stein B, Bromley B, Michlewitz H, Miller WA, Benacerraf BR Fetal liver calcifications:sonographic appearance and postnatal outcome Radiology 197: 489-92