Tricuspid valve regurgitation isolated

In this condition, there is tricuspid regurgitation in the absence of tricuspid valve abnormality. It may be mild, moderate or severe. Mild transient tricuspid regurgitation of no pathological significance is probably not uncommon, although less common than postnatally. If moderate or severe, there may be associated right atrial enlargement and cardiomegaly. It can be due to a tachycardia, sympathomimetic treatment, ductal constriction secondary to non-steroidal anti-inflammatory ingestion or be idiopathic. Tricuspid regurgitation precedes ductal constriction due to NSAIDs. It will usually resolve with cessation of the tachycardia or drug treatment. Tricuspid regurgitation per se does not usually cause compromise in the neonate. However, if it has been severe and longstanding in utero there may be some degree of secondary pulmonary hypoplasia.